The essay mentions causality briefly and Hughes does not evidently believe in the uncertainty of quantum futures and the fact that our matter is entangled with all of the matter in the universe. Quantum phase noise plays a particular role in our differentiation of a classical determinate reality from the many possible futures of the actual quantum reality in which we actually live.
In the end, though, Hughes essay does conclude that even though civilization is not very massive compared to the universe, the neural resonances and stories of civilization are most of what matters to us here on earth. So even though the size of the universe boggles the mind, so what?
"And whether or not they are objectively valuable, the ends that matter to us, the things that we care about most – our relationships, our projects and goals, our shared experiences, social justice, the pursuit of knowledge, the creation and appreciation of art, music and literature, and the future and fate of ours and other species – do not depend to any considerable extent on our having control over a vast but largely irrelevant Universe...Most of what matters to us is right here on Earth."
Also, the matter equivalent energy needed to maintain 1 g acceleration for 15 years is beyond science today but there might be ways to use galaxy spiral gravity boosts for a journey at this scale. Gravity waves, after all, are something that science is just learning about and so maybe we can catch a gravity wave and surf our way to the galaxy center. It would take the matter equivalent of ~600 MW nuclear reactor to accelerate a 100 MT ship at 1 g for a year.
We do matter in the cosmos since it is us who determines what matters to us and not anybody outside of our own local universe. The definition of a universe is the matter and action that we affect and that affects us during our lives. The universe that we imagine does not exist until we experience that universe and so we are in fact the most important part of our own universe since neither it nor its uncertain future would exist without us.